Tretinoin

僅用于工業(yè)應(yīng)用或科學(xué)研究，不可用于人類(lèi)或動(dòng)物的臨床診斷或治療，非藥用.Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.Retinoic acid 是維生素 A 的代謝產(chǎn)物，在細(xì)胞生長(zhǎng)，分化和器官發(fā)生中起重要作用。Retinoic acid 是 RAR 核受體的天然激動(dòng)劑，對(duì) RARα/β/γ的 IC50 為14 nM。 Retinoic acid與 PPARβ/δ 結(jié)合的 Kd 值為 17 nM。Retinoic acid 可以通過(guò)激活視黃酸受體抑制轉(zhuǎn)錄因子 Nrf2